Description
Interleukin 12 (IL12) is also known as p70, and is an interleukin that is naturally produced by dendritic cells, macrophages and human B-lymphoblastoid cells (NC-37) in response to antigenic stimulation.IL12 is a heterodimeric cytokine, containing IL-12A (p35) and IL-12B (p40).
IL-12 is involved in the differentiation of naive T cells into Th1 cells.
It is known as a T cell-stimulating factor, which can stimulate the growth and function of T cells.
It stimulates the production of IFN-γ and TNF-α from T cells and NK cells, and reduces IL-4 mediated suppression of IFN-γ.
IL-12 plays an important role in the activities of natural killer cells and T lymphocytes.
IL-12 also has anti-angiogenic activity, which means it can block the formation of new blood vessels